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Crosstalk Between Chaperone-Mediated Protein Disaggregation and Proteolytic Pathways in Aging and Disease

A functional protein quality control machinery is crucial to maintain cellular and organismal physiology. Perturbation in the protein homeostasis network can lead to the formation of misfolded and aggregated proteins that are a hallmark of protein conformational disorders and aging. Protein aggregat...

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Detalles Bibliográficos
Autores principales: Feleciano, Diogo R., Juenemann, Katrin, Iburg, Manuel, Brás, Inês C., Holmberg, Carina I., Kirstein, Janine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361847/
https://www.ncbi.nlm.nih.gov/pubmed/30760997
http://dx.doi.org/10.3389/fnagi.2019.00009