CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary

Inactivating mutations in SMARCA4 (BRG1), a key SWI/SNF chromatin remodelling gene, underlie small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). To reveal its druggable vulnerabilities, we perform kinase-focused RNAi screens and uncover that SMARCA4-deficient SCCOHT cells are highly sens...

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Detalles Bibliográficos
Autores principales: Xue, Yibo, Meehan, Brian, Macdonald, Elizabeth, Venneti, Sriram, Wang, Xue Qing D., Witkowski, Leora, Jelinic, Petar, Kong, Tim, Martinez, Daniel, Morin, Geneviève, Firlit, Michelle, Abedini, Atefeh, Johnson, Radia M., Cencic, Regina, Patibandla, Jay, Chen, Hongbo, Papadakis, Andreas I., Auguste, Aurelie, de Rink, Iris, Kerkhoven, Ron M., Bertos, Nicholas, Gotlieb, Walter H., Clarke, Blaise A., Leary, Alexandra, Witcher, Michael, Guiot, Marie-Christine, Pelletier, Jerry, Dostie, Josée, Park, Morag, Judkins, Alexander R., Hass, Ralf, Levine, Douglas A., Rak, Janusz, Vanderhyden, Barbara, Foulkes, William D., Huang, Sidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361890/
https://www.ncbi.nlm.nih.gov/pubmed/30718512
http://dx.doi.org/10.1038/s41467-018-06958-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361890/
https://www.ncbi.nlm.nih.gov/pubmed/30718512
http://dx.doi.org/10.1038/s41467-018-06958-9

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