β-arrestin-2 in PAR-1-biased signaling has a crucial role in endothelial function via PDGF-β in stroke

Thrombin aggravates ischemic stroke and activated protein C (APC) has a neuroprotective effect. Both proteases interact with protease-activated receptor 1, which exhibits functional selectivity and leads to G-protein- and β-arrestin-mediated-biased signal transduction. We focused on the effect of β-...

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Detalles Bibliográficos
Autores principales: Kanki, Hideaki, Sasaki, Tsutomu, Matsumura, Shigenobu, Yokawa, Satoru, Yukami, Toshiro, Shimamura, Munehisa, Sakaguchi, Manabu, Furuno, Tadahide, Suzuki, Takahiro, Mochizuki, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361911/
https://www.ncbi.nlm.nih.gov/pubmed/30718498
http://dx.doi.org/10.1038/s41419-019-1375-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361911/
https://www.ncbi.nlm.nih.gov/pubmed/30718498
http://dx.doi.org/10.1038/s41419-019-1375-x

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