Modeling spinocerebellar ataxias 2 and 3 with iPSCs reveals a role for glutamate in disease pathology

Spinocerebellar ataxias 2 and 3 (SCA2 and SCA3) are dominantly inherited neurodegenerative diseases caused by expansion of polyglutamine-encoding CAG repeats in the affected genes. The etiology of these disorders is known to involve widespread loss of neuronal cells in the cerebellum, however, the m...

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Detalles Bibliográficos
Autores principales: Chuang, Ching-Yu, Yang, Chih-Chao, Soong, Bing-Wen, Yu, Chun-Ying, Chen, Shu-Hwa, Huang, Hsiang-Po, Kuo, Hung-Chih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361947/
https://www.ncbi.nlm.nih.gov/pubmed/30718627
http://dx.doi.org/10.1038/s41598-018-37774-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361947/
https://www.ncbi.nlm.nih.gov/pubmed/30718627
http://dx.doi.org/10.1038/s41598-018-37774-2

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