Contribution of syndecans to cellular internalization and fibrillation of amyloid-β(1–42)

Intraneuronal accumulation of amyloid-β(1–42) (Aβ1–42) is one of the earliest signs of Alzheimer’s disease (AD). Cell surface heparan sulfate proteoglycans (HSPGs) have profound influence on the cellular uptake of Aβ1–42 by mediating its attachment and subsequent internalization into the cells. Colo...

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Detalles Bibliográficos
Autores principales: Letoha, Tamás, Hudák, Anett, Kusz, Erzsébet, Pettkó-Szandtner, Aladár, Domonkos, Ildikó, Jósvay, Katalin, Hofmann-Apitius, Martin, Szilák, László
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362000/
https://www.ncbi.nlm.nih.gov/pubmed/30718543
http://dx.doi.org/10.1038/s41598-018-37476-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362000/
https://www.ncbi.nlm.nih.gov/pubmed/30718543
http://dx.doi.org/10.1038/s41598-018-37476-9

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