Identification of Novel Regulatory Genes in APAP Induced Hepatocyte Toxicity by a Genome-Wide CRISPR-Cas9 Screen

Acetaminophen (APAP) is a commonly used analgesic responsible for more than half of acute liver failure cases. Identification of previously unknown genetic risk factors would provide mechanistic insights and novel therapeutic targets for APAP-induced liver injury. This study used a genome-wide CRISP...

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Detalles Bibliográficos
Autores principales: Shortt, Katherine, Heruth, Daniel P., Zhang, NiNi, Wu, Weibin, Singh, Shipra, Li, Ding-You, Zhang, Li Qin, Wyckoff, Gerald J., Qi, Lei S., Friesen, Craig A., Ye, Shui Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362041/
https://www.ncbi.nlm.nih.gov/pubmed/30718897
http://dx.doi.org/10.1038/s41598-018-37940-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362041/
https://www.ncbi.nlm.nih.gov/pubmed/30718897
http://dx.doi.org/10.1038/s41598-018-37940-6

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