Cargando…

Pigment epithelium-derived factor mediates retinal ganglion cell neuroprotection by suppression of caspase-2

Retinal ganglion cells (RGCs) undergo rapid cell death by apoptosis after injury but can be rescued by suppression of caspase-2 (CASP2) using an siRNA to CASP2 (siCASP2). Pigment epithelium-derived factor (PEDF), has neuroprotective and anti-angiogenic functions and protects RGC from death. The purp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vigneswara, Vasanthy, Ahmed, Zubair
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362048/ https://www.ncbi.nlm.nih.gov/pubmed/30718480 http://dx.doi.org/10.1038/s41419-019-1379-6

Ejemplares similares

Eye drop delivery of pigment epithelium-derived factor-34 promotes retinal ganglion cell neuroprotection and axon regeneration
por: Vigneswara, Vasanthy, et al.
Publicado: (2015)

Pharmacological Inhibition of Caspase-2 Protects Axotomised Retinal Ganglion Cells from Apoptosis in Adult Rats
por: Vigneswara, Vasanthy, et al.
Publicado: (2012)

Pigment Epithelium-Derived Factor Promotes Axon Regeneration and Functional Recovery After Spinal Cord Injury
por: Stevens, Andrew R., et al.
Publicado: (2019)

Long-term neuroprotection of retinal ganglion cells by inhibiting caspase-2
por: Vigneswara, V, et al.
Publicado: (2016)

The Role of Caspase-2 in Regulating Cell Fate
por: Vigneswara, Vasanthy, et al.
Publicado: (2020)

Caspase-2 Is Upregulated after Sciatic Nerve Transection and Its Inhibition Protects Dorsal Root Ganglion Neurons from Apoptosis after Serum Withdrawal
por: Vigneswara, Vasanthy, et al.
Publicado: (2013)

Pigment epithelium-derived factor protects retinal ganglion cells
por: Pang, Iok-Hou, et al.
Publicado: (2007)

Pigment Epithelium-Derived Factor Released by Müller Glial Cells Exerts Neuroprotective Effects on Retinal Ganglion Cells
por: Unterlauft, Jan Darius, et al.
Publicado: (2012)

Caspases in retinal ganglion cell death and axon regeneration
por: Thomas, Chloe N, et al.
Publicado: (2017)

Receptor Tyrosine Kinases: Molecular Switches Regulating CNS Axon Regeneration
por: Vigneswara, Vasanthy, et al.
Publicado: (2012)

Retinal Pigment Epithelium Derived Stem Cells
por: Hiscott, Paul, et al.
Publicado: (2009)

Detection of Retinal Pigment Epithelium-Specific Antibody in iPSC-Derived Retinal Pigment Epithelium Transplantation Models
por: Sugita, Sunao, et al.
Publicado: (2017)

MIND4-17 protects retinal pigment epithelium cells and retinal ganglion cells from UV
por: Li, Chaopeng, et al.
Publicado: (2017)

TNFα-Mediated Priming of Mesenchymal Stem Cells Enhances Their Neuroprotective Effect on Retinal Ganglion Cells
por: Mead, Ben, et al.
Publicado: (2020)

Pigment Epithelium-Derived Factor Secreted from Retinal Pigment Epithelium Facilitates Apoptotic Cell Death of iPSC
por: Kanemura, Hoshimi, et al.
Publicado: (2013)

Degradation of Photoreceptor Outer Segments by the Retinal Pigment Epithelium Requires Pigment Epithelium-Derived Factor Receptor (PEDF-R)
por: Bullock, Jeanee, et al.
Publicado: (2021)

Effect of Photobiomodulation in Suppression of Oxidative Stress on Retinal Pigment Epithelium
por: Kim, Jongmin, et al.
Publicado: (2022)

Inhibition of Autophagy Suppresses Sertraline-Mediated Primary Ciliogenesis in Retinal Pigment Epithelium Cells
por: Kim, Eun Sung, et al.
Publicado: (2015)

Stem Cell Derived Retinal Pigment Epithelium: The Role of Pigmentation as Maturation Marker and Gene Expression Profile Comparison with Human Endogenous Retinal Pigment Epithelium.
por: Bennis, A., et al.
Publicado: (2017)

Evaluation of focal damage in the retinal pigment epithelium layer in serous retinal pigment epithelium detachment
por: Miura, Masahiro, et al.
Publicado: (2019)

Bestrophin 2 is expressed in human non-pigmented ciliary epithelium but not retinal pigment epithelium
por: Zhang, Youwen, et al.
Publicado: (2010)

Pigment Epithelium-Derived Factor (PEDF) Receptors Are Involved in Survival of Retinal Neurons
por: Bürger, Susanne, et al.
Publicado: (2020)

Translocation of the retinal pigment epithelium and formation of sub-retinal pigment epithelium deposit induced by subretinal deposit
por: Zhao, Lian, et al.
Publicado: (2007)

Spermidine Oxidation-Mediated Degeneration of Retinal Pigment Epithelium in Rats
por: Ohashi, Koji, et al.
Publicado: (2017)

Setting Eyes on the Retinal Pigment Epithelium
por: Moreno-Marmol, Tania, et al.
Publicado: (2018)

Functions and Diseases of the Retinal Pigment Epithelium
por: Yang, Song, et al.
Publicado: (2021)

Carbachol-mediated pigment granule dispersion in retinal pigment epithelium requires Ca(2+ )and calcineurin
por: Johnson, Adam S, et al.
Publicado: (2007)

Impact of drusen and drusenoid retinal pigment epithelium elevation size and structure on the integrity of the retinal pigment epithelium layer
por: Schlanitz, Ferdinand, et al.
Publicado: (2019)

Common clinical features of unilateral retinal pigment epithelium dysgenesis and combined hamartoma of the retina and retinal pigment epithelium
por: Zhu, Zhe, et al.
Publicado: (2022)

Expression of pigment epithelium‐derived factor and thrombospondin‐1 regulate proliferation and migration of retinal pigment epithelial cells
por: Farnoodian, Mitra, et al.
Publicado: (2015)

Transcriptional comparison of adult human primary Retinal Pigment Epithelium, human pluripotent stem cell-derived Retinal Pigment Epithelium, and ARPE19 cells
por: Markert, Elke K., et al.
Publicado: (2022)

Caspase-14 Expression Impairs Retinal Pigment Epithelium Barrier Function: Potential Role in Diabetic Macular Edema
por: Beasley, Selina, et al.
Publicado: (2014)

CNTF Mediates Neurotrophic Factor Secretion and Fluid Absorption in Human Retinal Pigment Epithelium
por: Li, Rong, et al.
Publicado: (2011)

Efficient induction of productive Cre-mediated recombination in retinal pigment epithelium
por: Fu, Shuhua, et al.
Publicado: (2014)

PTEN Reduced UVB-Mediated Apoptosis in Retinal Pigment Epithelium Cells
por: He, Jia, et al.
Publicado: (2017)

Identification of Mesencephalic Astrocyte-Derived Neurotrophic Factor as a Novel Neuroprotective Factor for Retinal Ganglion Cells
por: Gao, Feng-Juan, et al.
Publicado: (2017)

Components of the cytoskeleton in the retinal pigmented epithelium of the chick
Publicado: (1985)

Characterization of the retinal pigment epithelium in Friedreich ataxia
por: Crombie, Duncan E., et al.
Publicado: (2015)

Retinal pigment epithelium changes in Kartagener syndrome
por: Garcia, Maria D., et al.
Publicado: (2018)

Simple Congenital Hamartoma of the Retinal Pigment Epithelium
por: Nakatsuka, Austin S., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_2lt54p76hdoms09j8ibln2cinm