A cancer-associated point mutation disables the steric gate of human PrimPol

PrimPol is a human primase/polymerase specialized in re-starting stalled forks by repriming beyond lesions such as pyrimidine dimers, and replication-perturbing structures including G-quadruplexes and R-loops. Unlike most conventional primases, PrimPol proficiently discriminates against ribonucleoti...

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Detalles Bibliográficos
Autores principales: Díaz-Talavera, Alberto, Calvo, Patricia A., González-Acosta, Daniel, Díaz, Marcos, Sastre-Moreno, Guillermo, Blanco-Franco, Luis, Guerra, Susana, Martínez-Jiménez, Maria I., Méndez, Juan, Blanco, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362072/
https://www.ncbi.nlm.nih.gov/pubmed/30718533
http://dx.doi.org/10.1038/s41598-018-37439-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362072/
https://www.ncbi.nlm.nih.gov/pubmed/30718533
http://dx.doi.org/10.1038/s41598-018-37439-0

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