Physical principles of retroviral integration in the human genome

Certain retroviruses, including HIV, insert their DNA in a non-random fraction of the host genome via poorly understood selection mechanisms. Here, we develop a biophysical model for retroviral integration as stochastic and quasi-equilibrium topological reconnections between polymers. We discover th...

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Detalles Bibliográficos
Autores principales: Michieletto, D., Lusic, M., Marenduzzo, D., Orlandini, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362086/
https://www.ncbi.nlm.nih.gov/pubmed/30718508
http://dx.doi.org/10.1038/s41467-019-08333-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362086/
https://www.ncbi.nlm.nih.gov/pubmed/30718508
http://dx.doi.org/10.1038/s41467-019-08333-8

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