Pharmacophore-guided discovery of CDC25 inhibitors causing cell cycle arrest and tumor regression

CDC25 phosphatases play a key role in cell cycle transitions and are important targets for cancer therapy. Here, we set out to discover novel CDC25 inhibitors. Using a combination of computational methods, we defined a minimal common pharmacophore in established CDC25 inhibitors and performed virtua...

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Detalles Bibliográficos
Autores principales: Kabakci, Zeynep, Käppeli, Simon, Cantù, Claudio, Jensen, Lasse D., König, Christiane, Toggweiler, Janine, Gentili, Christian, Ribaudo, Giovanni, Zagotto, Giuseppe, Basler, Konrad, Pinna, Lorenzo A., Cozza, Giorgio, Ferrari, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362118/
https://www.ncbi.nlm.nih.gov/pubmed/30718768
http://dx.doi.org/10.1038/s41598-019-38579-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362118/
https://www.ncbi.nlm.nih.gov/pubmed/30718768
http://dx.doi.org/10.1038/s41598-019-38579-7

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