pH-driven conformational switch between non-canonical DNA structures in a C-rich domain of EGFR promoter

EGFR is an oncogene that encodes for a trans-membrane tyrosine kinase receptor. Its mis-regulation is associated to several human cancers that, consistently, can be treated by selective tyrosine kinase inhibitors. The proximal promoter of EGFR contains a G-rich domain located at 272 bases upstream t...

Descripción completa

Detalles Bibliográficos
Autores principales: Cristofari, Camilla, Rigo, Riccardo, Greco, Maria Laura, Ghezzo, Michele, Sissi, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362134/
https://www.ncbi.nlm.nih.gov/pubmed/30718769
http://dx.doi.org/10.1038/s41598-018-37968-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362134/
https://www.ncbi.nlm.nih.gov/pubmed/30718769
http://dx.doi.org/10.1038/s41598-018-37968-8

Ejemplares similares