High-resolution experimental and computational electrophysiology reveals weak β-lactam binding events in the porin PorB

The permeation of most antibiotics through the outer membrane of Gram-negative bacteria occurs through porin channels. To design drugs with increased activity against Gram-negative bacteria in the face of the antibiotic resistance crisis, the strict constraints on the physicochemical properties of t...

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Detalles Bibliográficos
Autores principales: Bartsch, Annika, Llabrés, Salomé, Pein, Florian, Kattner, Christof, Schön, Markus, Diehn, Manuel, Tanabe, Mikio, Munk, Axel, Zachariae, Ulrich, Steinem, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362148/
https://www.ncbi.nlm.nih.gov/pubmed/30718567
http://dx.doi.org/10.1038/s41598-018-37066-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362148/
https://www.ncbi.nlm.nih.gov/pubmed/30718567
http://dx.doi.org/10.1038/s41598-018-37066-9

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