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High-resolution experimental and computational electrophysiology reveals weak β-lactam binding events in the porin PorB
The permeation of most antibiotics through the outer membrane of Gram-negative bacteria occurs through porin channels. To design drugs with increased activity against Gram-negative bacteria in the face of the antibiotic resistance crisis, the strict constraints on the physicochemical properties of t...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362148/ https://www.ncbi.nlm.nih.gov/pubmed/30718567 http://dx.doi.org/10.1038/s41598-018-37066-9 |