Utilizing mixer torque rheometer in the prediction of optimal wet massing parameters for pellet formulation by extrusion/spheronization

In this study, we aimed to optimize theophylline pellet formulations using a two-factor three-level full-factorial design (3(2)) by monitoring the concentration of two pellet excipients, polyvinyl pyrrolidone K30 (PVP) binder solution (X1) and the hydrophilic excipient mannitol (X2). Their impact on...

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Detalles Bibliográficos
Autores principales: Ibrahim, Mohamed A., Zayed, Gamal M., Alsharif, Fahd M., Abdelhafez, Wael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362277/
https://www.ncbi.nlm.nih.gov/pubmed/30766428
http://dx.doi.org/10.1016/j.jsps.2018.10.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362277/
https://www.ncbi.nlm.nih.gov/pubmed/30766428
http://dx.doi.org/10.1016/j.jsps.2018.10.002

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