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Utilizing mixer torque rheometer in the prediction of optimal wet massing parameters for pellet formulation by extrusion/spheronization
In this study, we aimed to optimize theophylline pellet formulations using a two-factor three-level full-factorial design (3(2)) by monitoring the concentration of two pellet excipients, polyvinyl pyrrolidone K30 (PVP) binder solution (X1) and the hydrophilic excipient mannitol (X2). Their impact on...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362277/ https://www.ncbi.nlm.nih.gov/pubmed/30766428 http://dx.doi.org/10.1016/j.jsps.2018.10.002 |