DPP8/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophages

Activating germline mutations in the human inflammasome sensor NLRP1 causes palmoplantar dyskeratosis and susceptibility to Mendelian autoinflammatory diseases. Recent studies have shown that the cytosolic serine dipeptidyl peptidases DPP8 and DPP9 suppress inflammasome activation upstream of NLRP1...

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Detalles Bibliográficos
Autores principales: de Vasconcelos, Nathalia M, Vliegen, Gwendolyn, Gonçalves, Amanda, De Hert, Emilie, Martín-Pérez, Rosa, Van Opdenbosch, Nina, Jallapally, Anvesh, Geiss-Friedlander, Ruth, Lambeir, Anne-Marie, Augustyns, Koen, Van Der Veken, Pieter, De Meester, Ingrid, Lamkanfi, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362307/
https://www.ncbi.nlm.nih.gov/pubmed/30718379
http://dx.doi.org/10.26508/lsa.201900313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362307/
https://www.ncbi.nlm.nih.gov/pubmed/30718379
http://dx.doi.org/10.26508/lsa.201900313

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