Nuclear pore density controls heterochromatin reorganization during senescence

During oncogene-induced senescence (OIS), heterochromatin is lost from the nuclear periphery and forms internal senescence-associated heterochromatin foci (SAHFs). We show that an increased nuclear pore density during OIS is responsible for SAHF formation. In particular, the nucleoporin TPR is neces...

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Detalles Bibliográficos
Autores principales: Boumendil, Charlene, Hari, Priya, Olsen, Karl C.F., Acosta, Juan Carlos, Bickmore, Wendy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362808/
https://www.ncbi.nlm.nih.gov/pubmed/30692205
http://dx.doi.org/10.1101/gad.321117.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362808/
https://www.ncbi.nlm.nih.gov/pubmed/30692205
http://dx.doi.org/10.1101/gad.321117.118

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