Nuclear pore density controls heterochromatin reorganization during senescence

During oncogene-induced senescence (OIS), heterochromatin is lost from the nuclear periphery and forms internal senescence-associated heterochromatin foci (SAHFs). We show that an increased nuclear pore density during OIS is responsible for SAHF formation. In particular, the nucleoporin TPR is neces...

Descripción completa

Detalles Bibliográficos
Autores principales: Boumendil, Charlene, Hari, Priya, Olsen, Karl C.F., Acosta, Juan Carlos, Bickmore, Wendy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362808/
https://www.ncbi.nlm.nih.gov/pubmed/30692205
http://dx.doi.org/10.1101/gad.321117.118

Ejemplares similares

Ejemplares similares