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Afadin cooperates with Claudin-2 to promote breast cancer metastasis

Claudin-2 promotes breast cancer liver metastasis by enabling seeding and early cancer cell survival. We now demonstrate that the PDZ-binding motif of Claudin-2 is necessary for anchorage-independent growth of cancer cells and is required for liver metastasis. Several PDZ domain-containing proteins...

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Detalles Bibliográficos
Autores principales:	Tabariès, Sébastien, McNulty, Alexander, Ouellet, Véronique, Annis, Matthew G., Dessureault, Mireille, Vinette, Maude, Hachem, Yasmina, Lavoie, Brennan, Omeroglu, Atilla, Simon, Hans-Georg, Walsh, Logan A., Kimbung, Siker, Hedenfalk, Ingrid, Siegel, Peter M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362814/ https://www.ncbi.nlm.nih.gov/pubmed/30692208 http://dx.doi.org/10.1101/gad.319194.118

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