Impaired Expression of Rearranged Immunoglobulin Genes and Premature p53 Activation Block B Cell Development in BMI1 Null Mice

B cell development is a highly regulated process that requires stepwise rearrangement of immunoglobulin genes to generate a functional B cell receptor (BCR). The polycomb group protein BMI1 is required for B cell development, but its function in developing B cells remains poorly defined. We demonstr...

Descripción completa

Detalles Bibliográficos
Autores principales: Cantor, David J., King, Bryan, Blumenberg, Lili, DiMauro, Teresa, Aifantis, Iannis, Koralov, Sergei B., Skok, Jane A., David, Gregory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362848/
https://www.ncbi.nlm.nih.gov/pubmed/30605667
http://dx.doi.org/10.1016/j.celrep.2018.12.030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362848/
https://www.ncbi.nlm.nih.gov/pubmed/30605667
http://dx.doi.org/10.1016/j.celrep.2018.12.030

Ejemplares similares