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Children Are Not Small Adults, but Can We Treat Them As Such?

Although children cannot be considered small adults due to nonlinear processes underlying the pharmacokinetics of drugs, pediatric doses are typically still expressed per kilogram. We use a physiologically based pharmacokinetic (PBPK) workflow to assess the accuracy of linear scaling of plasma clear...

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Detalles Bibliográficos
Autores principales: Krekels, Elke H.J., Calvier, Elisa A.M., van der Graaf, Piet H., Knibbe, Catherijne A.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363065/
https://www.ncbi.nlm.nih.gov/pubmed/30689298
http://dx.doi.org/10.1002/psp4.12366