Systems biology reveals how altered TGFβ signalling with age reduces protection against pro-inflammatory stimuli

Osteoarthritis (OA) is a degenerative condition caused by dysregulation of multiple molecular signalling pathways. Such dysregulation results in damage to cartilage, a smooth and protective tissue that enables low friction articulation of synovial joints. Matrix metalloproteinases (MMPs), especially...

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Detalles Bibliográficos
Autores principales: Hodgson, David, Rowan, Andrew D., Falciani, Francesco, Proctor, Carole J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363221/
https://www.ncbi.nlm.nih.gov/pubmed/30677026
http://dx.doi.org/10.1371/journal.pcbi.1006685

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363221/
https://www.ncbi.nlm.nih.gov/pubmed/30677026
http://dx.doi.org/10.1371/journal.pcbi.1006685

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