Cellular acidosis triggers human MondoA transcriptional activity by driving mitochondrial ATP production

Human MondoA requires glucose as well as other modulatory signals to function in transcription. One such signal is acidosis, which increases MondoA activity and also drives a protective gene signature in breast cancer. How low pH controls MondoA transcriptional activity is unknown. We found that low...

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Detalles Bibliográficos
Autores principales: Wilde, Blake R, Ye, Zhizhou, Lim, Tian-Yeh, Ayer, Donald E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363388/
https://www.ncbi.nlm.nih.gov/pubmed/30717828
http://dx.doi.org/10.7554/eLife.40199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363388/
https://www.ncbi.nlm.nih.gov/pubmed/30717828
http://dx.doi.org/10.7554/eLife.40199

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