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Molecular dissection of multiphase inactivation of the bacterial sodium channel Na(V)Ab

Homotetrameric bacterial voltage-gated sodium channels share major biophysical features with their more complex eukaryotic counterparts, including a slow-inactivation mechanism that reduces ion-conductance activity during prolonged depolarization through conformational changes in the pore. The bacte...

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Detalles Bibliográficos
Autores principales: Gamal El-Din, Tamer M., Lenaeus, Michael J., Ramanadane, Karthik, Zheng, Ning, Catterall, William A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363407/
https://www.ncbi.nlm.nih.gov/pubmed/30510035
http://dx.doi.org/10.1085/jgp.201711884