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Molecular dissection of multiphase inactivation of the bacterial sodium channel Na(V)Ab
Homotetrameric bacterial voltage-gated sodium channels share major biophysical features with their more complex eukaryotic counterparts, including a slow-inactivation mechanism that reduces ion-conductance activity during prolonged depolarization through conformational changes in the pore. The bacte...
Autores principales: | Gamal El-Din, Tamer M., Lenaeus, Michael J., Ramanadane, Karthik, Zheng, Ning, Catterall, William A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363407/ https://www.ncbi.nlm.nih.gov/pubmed/30510035 http://dx.doi.org/10.1085/jgp.201711884 |
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