Extracellular protons accelerate hERG channel deactivation by destabilizing voltage sensor relaxation

hERG channels underlie the delayed-rectifier K(+) channel current (I(Kr)), which is crucial for membrane repolarization and therefore termination of the cardiac action potential. hERG channels display unusually slow deactivation gating, which contributes to a resurgent current upon repolarization an...

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Detalles Bibliográficos
Autores principales: Shi, Yu Patrick, Thouta, Samrat, Cheng, Yen May, Claydon, Tom W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363419/
https://www.ncbi.nlm.nih.gov/pubmed/30530765
http://dx.doi.org/10.1085/jgp.201812137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363419/
https://www.ncbi.nlm.nih.gov/pubmed/30530765
http://dx.doi.org/10.1085/jgp.201812137

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