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Extracellular protons accelerate hERG channel deactivation by destabilizing voltage sensor relaxation

hERG channels underlie the delayed-rectifier K(+) channel current (I(Kr)), which is crucial for membrane repolarization and therefore termination of the cardiac action potential. hERG channels display unusually slow deactivation gating, which contributes to a resurgent current upon repolarization an...

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Detalles Bibliográficos
Autores principales:	Shi, Yu Patrick, Thouta, Samrat, Cheng, Yen May, Claydon, Tom W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363419/ https://www.ncbi.nlm.nih.gov/pubmed/30530765 http://dx.doi.org/10.1085/jgp.201812137

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