Facilitation of I(Kr) current by some hERG channel blockers suppresses early afterdepolarizations

Drug-induced block of the cardiac rapid delayed rectifying potassium current (I(Kr)), carried by the human ether-a-go-go-related gene (hERG) channel, is the most common cause of acquired long QT syndrome. Indeed, some, but not all, drugs that block hERG channels cause fatal cardiac arrhythmias. Howe...

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Detalles Bibliográficos
Autores principales: Furutani, Kazuharu, Tsumoto, Kunichika, Chen, I-Shan, Handa, Kenichiro, Yamakawa, Yuko, Sack, Jon T., Kurachi, Yoshihisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363420/
https://www.ncbi.nlm.nih.gov/pubmed/30674563
http://dx.doi.org/10.1085/jgp.201812192

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363420/
https://www.ncbi.nlm.nih.gov/pubmed/30674563
http://dx.doi.org/10.1085/jgp.201812192

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