Cargando…

Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for PIK3CA-altered head and neck cancer

PIK3CA is the most commonly altered oncogene in head and neck squamous cell carcinoma (HNSCC). We evaluated the impact of nonsteroidal anti-inflammatory drugs (NSAIDs) on survival in a PIK3CA-characterized cohort of 266 HNSCC patients and explored the mechanism in relevant preclinical models includi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hedberg, Matthew L., Peyser, Noah D., Bauman, Julie E., Gooding, William E., Li, Hua, Bhola, Neil E., Zhu, Tian Ran, Zeng, Yan, Brand, Toni M., Kim, Mi-Ok, Jordan, Richard C.K., VandenBerg, Scott, Olivas, Victor, Bivona, Trever G., Chiosea, Simion I., Wang, Lin, Mills, Gordon B., Johnson, Jonas T., Duvvuri, Umamaheswar, Ferris, Robert L., Ha, Patrick, Johnson, Daniel E., Grandis, Jennifer R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363423/ https://www.ncbi.nlm.nih.gov/pubmed/30683736 http://dx.doi.org/10.1084/jem.20181936

Ejemplares similares

Phase I Study of Ficlatuzumab and Cetuximab in Cetuximab-Resistant, Recurrent/Metastatic Head and Neck Cancer
por: Bauman, Julie E., et al.
Publicado: (2020)

PIK3CA, HRAS and PTEN in human papillomavirus positive oropharyngeal squamous cell carcinoma
por: Chiosea, Simion I, et al.
Publicado: (2013)

Molecular Profile of Locally Aggressive Well Differentiated Thyroid Cancers
por: Mady, Leila J., et al.
Publicado: (2020)

TMEM16A/ANO1 is differentially expressed in HPV-negative versus HPV-positive head and neck squamous cell carcinoma through promoter methylation
por: Dixit, Ronak, et al.
Publicado: (2015)

NSAIDs Overcome PIK3CA Mutation-Mediated Resistance to EGFR Inhibition in Head and Neck Cancer Preclinical Models
por: Li, Hua, et al.
Publicado: (2022)

Impact of the Multi-Gene ThyroSeq Next-Generation Sequencing Assay on Cancer Diagnosis in Thyroid Nodules with Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance Cytology
por: Nikiforov, Yuri E., et al.
Publicado: (2015)

Genomic and Transcriptomic Alterations Associated with STAT3 Activation in Head and Neck Cancer
por: Peyser, Noah D., et al.
Publicado: (2016)

Profiling the Stromal and Vascular Heterogeneity in Patient-derived Xenograft Models of Head and Neck Cancer: Impact on Therapeutic Response
por: Folaron, Margaret, et al.
Publicado: (2019)

Definitive local therapy to head and neck squamous cell carcinoma with distant metastasis
por: Borson, Steven, et al.
Publicado: (2022)

Long-Term Patient-Reported Quality of Life After Stereotactic Body Radiation Therapy for Recurrent, Previously-Irradiated Head and Neck Cancer
por: Thomas, Joel, et al.
Publicado: (2020)

Caveolin-1 and Sox-2 are predictive biomarkers of cetuximab response in head and neck cancer
por: Bouhaddou, Mehdi, et al.
Publicado: (2021)

4373 Defining the role of non-canonical PIK3CA mutations in head and neck squamous cell carcinoma
por: Lee, Michelle Ji-Eun, et al.
Publicado: (2020)

HER3 targeting potentiates growth suppressive effects of the PI3K inhibitor BYL719 in pre-clinical models of head and neck squamous cell carcinoma
por: Meister, Kara S., et al.
Publicado: (2019)

EGFR targeted therapy resistance: current status, challenges, and future outlook
por: Bivona, Trever G.
Publicado: (2020)

Interleukin 6 is increased in preclinical HNSCC models of acquired cetuximab resistance, but is not required for maintenance of resistance
por: O’Keefe, Rachel A., et al.
Publicado: (2020)

Surgeon satisfaction and outcomes of tele-proctoring for robotic gynecologic surgery
por: Artsen, Amanda M., et al.
Publicado: (2021)

Assessing the learning curve associated with a novel flexible robot in the pre-clinical and clinical setting
por: Zhu, Toby S., et al.
Publicado: (2021)

Mechanisms of Resistance to Epidermal Growth Factor Receptor Inhibitors and Novel Therapeutic Strategies to Overcome Resistance in NSCLC Patients
por: Lin, Luping, et al.
Publicado: (2012)

Adaptive stress signaling in targeted therapy resistance in cancer
por: Pazarentzos, Evangelos, et al.
Publicado: (2015)

Resistance is futile: overcoming resistance to targeted therapies in lung adenocarcinoma
por: Neel, Dana S., et al.
Publicado: (2017)

Targeting AXL in NSCLC
por: Zaman, Aubhishek, et al.
Publicado: (2021)

Remodeling of the tumor/tumor microenvironment ecosystem during KRAS G12C inhibitor clinical resistance in lung cancer
por: Manabe, Tadashi, et al.
Publicado: (2022)

Quantitative Framework for Bench-to-Bedside Cancer Research
por: Zaman, Aubhishek, et al.
Publicado: (2022)

Nonsteroidal Anti-Inflammatory Drugs and Risk of Melanoma
por: Jeter, Joanne M., et al.
Publicado: (2011)

Frequent promoter hypermethylation of PTPRT increases STAT3 activation and sensitivity to STAT3 inhibition in head and neck cancer
por: Peyser, Noah D., et al.
Publicado: (2015)

AXL receptor tyrosine kinase as a therapeutic target in NSCLC
por: Okimoto, Ross A, et al.
Publicado: (2015)

Intraoperative identification of the human communicating nerve during thyroidectomy
por: Hodnett, Benjamin L., et al.
Publicado: (2015)

Non-Canonical Thinking for Targeting ALK-Fusion Onco-Proteins in Lung Cancer
por: Wu, Wei, et al.
Publicado: (2017)

Targeting Oncogenic BRAF: Past, Present, and Future
por: Zaman, Aubhishek, et al.
Publicado: (2019)

EGF receptor signaling, phosphorylation, ubiquitylation and endocytosis in tumors in vivo
por: Pinilla-Macua, Itziar, et al.
Publicado: (2017)

Long Non-Coding RNAs as Emerging Targets in Lung Cancer
por: Gencel-Augusto, Jovanka, et al.
Publicado: (2023)

Transoral surgery for oropharyngeal tumors using the Medrobotics(®) Flex(®) System – a case report
por: Mandapathil, Magis, et al.
Publicado: (2015)

Critical analysis of the potential for targeting STAT3 in human malignancy
por: Peyser, Noah D, et al.
Publicado: (2013)

Nonsteroid management of residual ocular surface disease on dupilumab (ROSDD),()()
por: Raffi, Jodie, et al.
Publicado: (2019)

Nonsteroidal anti-inflammatory drug-induced acute ulcers in the colon
por: Katsanos, Konstantinos H., et al.
Publicado: (2011)

Circulating exosomes measure responses to therapy in head and neck cancer patients treated with cetuximab, ipilimumab, and IMRT
por: Theodoraki, Marie-Nicole, et al.
Publicado: (2019)

In vitro FRAP reveals the ATP-dependent nuclear mobilization of the exon junction complex protein SRm160
por: Wagner, Stefan, et al.
Publicado: (2004)

Nonsteroidal Anti-Inflammatory Drugs and the Kidney
por: Hörl, Walter H.
Publicado: (2010)

Nonsteroidal Topical Immunomodulators in Allergology and Dermatology
por: Jovanović, Marina, et al.
Publicado: (2016)

Nonsteroidal anti‐inflammatory drugs and pharyngitis
por: Mazzone, Stuart B, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_sk1djbr01e5l260j7r6644p0vs