Gene therapy targeting SARM1 blocks pathological axon degeneration in mice

Axonal degeneration (AxD) following nerve injury, chemotherapy, and in several neurological disorders is an active process driven by SARM1, an injury-activated NADase. Axons of SARM1-null mice exhibit greatly delayed AxD after transection and in models of neurological disease, suggesting that inhibi...

Descripción completa

Detalles Bibliográficos
Autores principales: Geisler, Stefanie, Huang, Shay X., Strickland, Amy, Doan, Ryan A., Summers, Daniel W., Mao, Xianrong, Park, Jiwoong, DiAntonio, Aaron, Milbrandt, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363435/
https://www.ncbi.nlm.nih.gov/pubmed/30642945
http://dx.doi.org/10.1084/jem.20181040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363435/
https://www.ncbi.nlm.nih.gov/pubmed/30642945
http://dx.doi.org/10.1084/jem.20181040

Ejemplares similares