TPX2 joins 53BP1 to maintain DNA repair and fork stability

In this issue, Byrum et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201803003) surprisingly identify an interaction between 53BP1 and the mitotic regulators TPX2 and Aurora A that lead them to novel mechanistic insights about DNA double-stranded break repair regulation and a new fork protec...

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Detalles Bibliográficos
Autor principal: Cantor, Sharon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363450/
https://www.ncbi.nlm.nih.gov/pubmed/30635354
http://dx.doi.org/10.1083/jcb.201812142
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author Cantor, Sharon
author_facet Cantor, Sharon
author_sort Cantor, Sharon
collection PubMed
description In this issue, Byrum et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201803003) surprisingly identify an interaction between 53BP1 and the mitotic regulators TPX2 and Aurora A that lead them to novel mechanistic insights about DNA double-stranded break repair regulation and a new fork protection pathway during replication stress.
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spelling pubmed-63634502019-08-04 TPX2 joins 53BP1 to maintain DNA repair and fork stability Cantor, Sharon J Cell Biol Commentaries In this issue, Byrum et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201803003) surprisingly identify an interaction between 53BP1 and the mitotic regulators TPX2 and Aurora A that lead them to novel mechanistic insights about DNA double-stranded break repair regulation and a new fork protection pathway during replication stress. Rockefeller University Press 2019-02-04 /pmc/articles/PMC6363450/ /pubmed/30635354 http://dx.doi.org/10.1083/jcb.201812142 Text en © 2019 Cantor http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentaries
Cantor, Sharon
TPX2 joins 53BP1 to maintain DNA repair and fork stability
title TPX2 joins 53BP1 to maintain DNA repair and fork stability
title_full TPX2 joins 53BP1 to maintain DNA repair and fork stability
title_fullStr TPX2 joins 53BP1 to maintain DNA repair and fork stability
title_full_unstemmed TPX2 joins 53BP1 to maintain DNA repair and fork stability
title_short TPX2 joins 53BP1 to maintain DNA repair and fork stability
title_sort tpx2 joins 53bp1 to maintain dna repair and fork stability
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363450/
https://www.ncbi.nlm.nih.gov/pubmed/30635354
http://dx.doi.org/10.1083/jcb.201812142
work_keys_str_mv AT cantorsharon tpx2joins53bp1tomaintaindnarepairandforkstability

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