Toll-Like Receptor Signaling Drives Btk-Mediated Autoimmune Disease

Bruton's tyrosine kinase (Btk) is a signaling molecule involved in development and activation of B cells through B-cell receptor (BCR) and Toll-like receptor (TLR) signaling. We have previously shown that transgenic mice that overexpress human Btk under the control of the CD19 promoter (CD19-hB...

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Detalles Bibliográficos
Autores principales: Rip, Jasper, de Bruijn, Marjolein J. W., Appelman, Marjolein K., Pal Singh, Simar, Hendriks, Rudi W., Corneth, Odilia B. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363707/
https://www.ncbi.nlm.nih.gov/pubmed/30761150
http://dx.doi.org/10.3389/fimmu.2019.00095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363707/
https://www.ncbi.nlm.nih.gov/pubmed/30761150
http://dx.doi.org/10.3389/fimmu.2019.00095

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