Pharmacokinetic-Pharmacodynamic Modeling for Coptisine Challenge of Inflammation in LPS-Stimulated Rats

Pro-inflammatory factors are important indicators for assessing inflammation severity and drug efficacy. Coptisine has been reported to inhibit LPS-induced TNF-α and NO production. In this study, we aim to build a pharmacokinetic-pharmacodynamic model to quantify the coptisine time course and potenc...

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Detalles Bibliográficos
Autores principales: Hu, Yingfan, Wang, Li, Xiang, Li, Wu, Jiasi, Huang, Wen’ge, Xu, Chensi, Meng, Xianli, Wang, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363730/
https://www.ncbi.nlm.nih.gov/pubmed/30723253
http://dx.doi.org/10.1038/s41598-018-38164-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363730/
https://www.ncbi.nlm.nih.gov/pubmed/30723253
http://dx.doi.org/10.1038/s41598-018-38164-4

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