Tracing cellular heterogeneity in pooled genetic screens via multi-level barcoding

BACKGROUND: While pooled loss- and gain-of-function CRISPR screening approaches have become increasingly popular to systematically investigate mammalian gene function, the large majority of them have thus far not investigated the influence of cellular heterogeneity on screen results. Instead most sc...

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Detalles Bibliográficos
Autores principales: Boettcher, Michael, Covarrubias, Sergio, Biton, Anne, Blau, James, Wang, Haopeng, Zaitlen, Noah, McManus, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364396/
https://www.ncbi.nlm.nih.gov/pubmed/30727954
http://dx.doi.org/10.1186/s12864-019-5480-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364396/
https://www.ncbi.nlm.nih.gov/pubmed/30727954
http://dx.doi.org/10.1186/s12864-019-5480-0

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