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Tracing cellular heterogeneity in pooled genetic screens via multi-level barcoding
BACKGROUND: While pooled loss- and gain-of-function CRISPR screening approaches have become increasingly popular to systematically investigate mammalian gene function, the large majority of them have thus far not investigated the influence of cellular heterogeneity on screen results. Instead most sc...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364396/ https://www.ncbi.nlm.nih.gov/pubmed/30727954 http://dx.doi.org/10.1186/s12864-019-5480-0 |