Constipation, deficit in colon contractions and alpha-synuclein inclusions within the colon precede motor abnormalities and neurodegeneration in the central nervous system in a mouse model of alpha-synucleinopathy

BACKGROUND: Gastrointestinal dysfunction can affect Parkinson’s disease (PD) patients long before the onset of motor symptoms. However, little is known about the relationship between gastrointestinal abnormalities and the development of PD. Contrary to other animal models, the human A53T alpha-synuc...

Descripción completa

Detalles Bibliográficos
Autores principales: Rota, Lucia, Pellegrini, Carolina, Benvenuti, Laura, Antonioli, Luca, Fornai, Matteo, Blandizzi, Corrado, Cattaneo, Antonino, Colla, Emanuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364448/
https://www.ncbi.nlm.nih.gov/pubmed/30774946
http://dx.doi.org/10.1186/s40035-019-0146-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364448/
https://www.ncbi.nlm.nih.gov/pubmed/30774946
http://dx.doi.org/10.1186/s40035-019-0146-z

Ejemplares similares