Structural progression of amyloid-β Arctic mutant aggregation in cells revealed by multiparametric imaging

The 42-amino-acid β-amyloid (Aβ42) is a critical causative agent in the pathology of Alzheimer's disease. The hereditary Arctic mutation of Aβ42 (E22G) leads to increased intracellular accumulation of β-amyloid in early-onset Alzheimer's disease. However, it remains largely unknown how the...

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Detalles Bibliográficos
Autores principales: Lu, Meng, Williamson, Neil, Mishra, Ajay, Michel, Claire H., Kaminski, Clemens F., Tunnacliffe, Alan, Kaminski Schierle, Gabriele S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2019
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364760/
https://www.ncbi.nlm.nih.gov/pubmed/30504224
http://dx.doi.org/10.1074/jbc.RA118.004511

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364760/
https://www.ncbi.nlm.nih.gov/pubmed/30504224
http://dx.doi.org/10.1074/jbc.RA118.004511

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