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Structural progression of amyloid-β Arctic mutant aggregation in cells revealed by multiparametric imaging

The 42-amino-acid β-amyloid (Aβ42) is a critical causative agent in the pathology of Alzheimer's disease. The hereditary Arctic mutation of Aβ42 (E22G) leads to increased intracellular accumulation of β-amyloid in early-onset Alzheimer's disease. However, it remains largely unknown how the...

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Detalles Bibliográficos
Autores principales:	Lu, Meng, Williamson, Neil, Mishra, Ajay, Michel, Claire H., Kaminski, Clemens F., Tunnacliffe, Alan, Kaminski Schierle, Gabriele S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2019
Materias:	Editors' Picks
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364760/ https://www.ncbi.nlm.nih.gov/pubmed/30504224 http://dx.doi.org/10.1074/jbc.RA118.004511

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