Blockade of fibroblast activation protein in combination with radiation treatment in murine models of pancreatic adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a fibrotic stroma with a poor lymphocyte infiltrate, in part driven by cancer-associated fibroblasts (CAFs). CAFs, which express fibroblast activation protein (FAP), contribute to immune escape via exclusion of anti-tumor CD8(+) T cells fro...

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Detalles Bibliográficos
Autores principales: Gunderson, Andrew J., Yamazaki, Tomoko, McCarty, Kayla, Phillips, Michaela, Alice, Alejandro, Bambina, Shelly, Zebertavage, Lauren, Friedman, David, Cottam, Benjamin, Newell, Pippa, Gough, Michael J., Crittenden, Marka R., Van der Veken, Pieter, Young, Kristina H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364920/
https://www.ncbi.nlm.nih.gov/pubmed/30726287
http://dx.doi.org/10.1371/journal.pone.0211117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364920/
https://www.ncbi.nlm.nih.gov/pubmed/30726287
http://dx.doi.org/10.1371/journal.pone.0211117

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