Arsenic-induced BRCA1 CpG promoter methylation is associated with the downregulation of ERα and resistance to tamoxifen in MCF7 breast cancer cells and mouse mammary tumor xenografts

A significant percentage (~30%) of estrogen receptor-α (ERα)-positive tumors become refractory to endocrine therapies; however, the mechanisms responsible for this resistance remain largely unknown. Chronic exposure to arsenic through foods and contaminated water has been linked to an increased inci...

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Detalles Bibliográficos
Autores principales: Selmin, Ornella I., Donovan, Micah G., Skovan, Bethany, Paine-Murieta, Gillian D., Romagnolo, Donato F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365020/
https://www.ncbi.nlm.nih.gov/pubmed/30664189
http://dx.doi.org/10.3892/ijo.2019.4687

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365020/
https://www.ncbi.nlm.nih.gov/pubmed/30664189
http://dx.doi.org/10.3892/ijo.2019.4687

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