Simultaneous B and T cell acute lymphoblastic leukemias in zebrafish driven by transgenic MYC: implications for oncogenesis and lymphopoiesis

Precursor-B cell acute lymphoblastic leukemia (pre-B ALL) is the most common pediatric cancer, but there are no useful zebrafish pre-B ALL models. We describe the first highly- penetrant zebrafish pre-B ALL, driven by human MYC. Leukemias express B lymphoblast-specific genes and are distinct from T...

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Detalles Bibliográficos
Autores principales: Borga, Chiara, Park, Gilseung, Foster, Clay, Burroughs-Garcia, Jessica, Marchesin, Matteo, Shah, Rikin, Hasan, Ameera, Ahmed, Syed T., Bresolin, Silvia, Batchelor, Lance, Scordino, Teresa, Miles, Rodney R., te Kronnie, Geertruy, Regens, James L., Frazer, J. Kimble
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365377/
https://www.ncbi.nlm.nih.gov/pubmed/30111845
http://dx.doi.org/10.1038/s41375-018-0226-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365377/
https://www.ncbi.nlm.nih.gov/pubmed/30111845
http://dx.doi.org/10.1038/s41375-018-0226-6

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