miR-22 suppresses DNA ligase III addiction in multiple myeloma

Multiple myeloma (MM) is a hematologic malignancy characterized by high genomic instability. Here we provide evidence that hyper-activation of DNA ligase III (LIG3) is crucial for genomic instability and survival of MM cells. LIG3 mRNA expression in MM patients correlates with shorter survival and e...

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Detalles Bibliográficos
Autores principales: Caracciolo, Daniele, Di Martino, Maria Teresa, Amodio, Nicola, Morelli, Eugenio, Montesano, Martina, Botta, Cirino, Scionti, Francesca, Talarico, Daniela, Altomare, Emanuela, Gallo Cantafio, Maria Eugenia, Zuccalà, Valeria, Maltese, Lorenza, Todoerti, Katia, Rossi, Marco, Arbitrio, Mariamena, Neri, Antonino, Tagliaferri, Pierosandro, Tassone, Pierfrancesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365379/
https://www.ncbi.nlm.nih.gov/pubmed/30120376
http://dx.doi.org/10.1038/s41375-018-0238-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365379/
https://www.ncbi.nlm.nih.gov/pubmed/30120376
http://dx.doi.org/10.1038/s41375-018-0238-2

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