FcαRI Dynamics Are Regulated by GSK-3 and PKCζ During Cytokine Mediated Inside-Out Signaling

IgA binding to FcαRI (CD89) is rapidly enhanced by cytokine induced inside-out signaling. Dephosphorylation of serine 263 in the intracellular tail of FcαRI by PP2A and PI3K activation are instrumental in this process. To further investigate these signaling pathways, we targeted downstream kinases o...

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Detalles Bibliográficos
Autores principales: ten Broeke, Toine, Honing, Henk, Brandsma, Arianne M., Jacobino, Shamir, Bakema, Jantine E., Kanters, Deon, van der Linden, Jan A. M., Bracke, Madelon, Koenderman, Leo, Leusen, Jeanette H. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365424/
https://www.ncbi.nlm.nih.gov/pubmed/30766540
http://dx.doi.org/10.3389/fimmu.2018.03191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365424/
https://www.ncbi.nlm.nih.gov/pubmed/30766540
http://dx.doi.org/10.3389/fimmu.2018.03191

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