A New Panel-Based Next-Generation Sequencing Method for ADME Genes Reveals Novel Associations of Common and Rare Variants With Expression in a Human Liver Cohort

We developed a panel-based NGS pipeline for comprehensive analysis of 340 genes involved in absorption, distribution, metabolism and excretion (ADME) of drugs, other xenobiotics, and endogenous substances. The 340 genes comprised phase I and II enzymes, drug transporters and regulator/modifier genes...

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Detalles Bibliográficos
Autores principales: Klein, Kathrin, Tremmel, Roman, Winter, Stefan, Fehr, Sarah, Battke, Florian, Scheurenbrand, Tim, Schaeffeler, Elke, Biskup, Saskia, Schwab, Matthias, Zanger, Ulrich M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365429/
https://www.ncbi.nlm.nih.gov/pubmed/30766545
http://dx.doi.org/10.3389/fgene.2019.00007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365429/
https://www.ncbi.nlm.nih.gov/pubmed/30766545
http://dx.doi.org/10.3389/fgene.2019.00007

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