Critical roles for the phosphatidylinositide 3-kinase isoforms p110β and p110γ in thrombopoietin-mediated priming of platelet function

Thrombopoietin (TPO) enhances platelet activation through activation of the tyrosine kinase; JAK2 and the lipid kinase phosphatidylinositide 3-kinase (PI3K). The aim of our study was to identify the PI3K isoforms involved in mediating the effect of TPO on platelet function and elucidate the underlyi...

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Detalles Bibliográficos
Autores principales: Moore, Samantha F., Smith, Nina R., Blair, Thomas A., Durrant, Tom N., Hers, Ingeborg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365529/
https://www.ncbi.nlm.nih.gov/pubmed/30728366
http://dx.doi.org/10.1038/s41598-018-37012-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365529/
https://www.ncbi.nlm.nih.gov/pubmed/30728366
http://dx.doi.org/10.1038/s41598-018-37012-9

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