Cargando…

Critical roles for the phosphatidylinositide 3-kinase isoforms p110β and p110γ in thrombopoietin-mediated priming of platelet function

Thrombopoietin (TPO) enhances platelet activation through activation of the tyrosine kinase; JAK2 and the lipid kinase phosphatidylinositide 3-kinase (PI3K). The aim of our study was to identify the PI3K isoforms involved in mediating the effect of TPO on platelet function and elucidate the underlyi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Moore, Samantha F., Smith, Nina R., Blair, Thomas A., Durrant, Tom N., Hers, Ingeborg
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365529/ https://www.ncbi.nlm.nih.gov/pubmed/30728366 http://dx.doi.org/10.1038/s41598-018-37012-9

Ejemplares similares

Deficiency of PI3-Kinase catalytic isoforms p110γ and p110δ in mice enhances the IL-17/G-CSF axis and induces neutrophilia
por: Bucher, Kirsten, et al.
Publicado: (2017)

The p110α and p110β Isoforms of Class I Phosphatidylinositol 3-Kinase Are Involved in Toll-Like Receptor 5 Signaling in Epithelial Cells
por: Ivison, Sabine M., et al.
Publicado: (2010)

Class I Phosphoinositide 3-Kinase PIK3CA/p110α and PIK3CB/p110β Isoforms in Endometrial Cancer
por: Mazloumi Gavgani, Fatemeh, et al.
Publicado: (2018)

Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor
por: Berenjeno, Inma M., et al.
Publicado: (2012)

Dominant Role of the p110β Isoform of PI3K over p110α in Energy Homeostasis Regulation by POMC and AgRP Neurons
por: Al-Qassab, Hind, et al.
Publicado: (2009)

Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis
por: Soler, Adriana, et al.
Publicado: (2013)

Roles of Gβγ in membrane recruitment and activation of p110γ/p101 phosphoinositide 3-kinase γ
por: Brock, Carsten, et al.
Publicado: (2003)

Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors
por: Tsolakos, N., et al.
Publicado: (2018)

Deficiency of p110δ Isoform of the Phosphoinositide 3 Kinase Leads to Enhanced Resistance to Leishmania donovani
por: Khadem, Forough, et al.
Publicado: (2014)

Oncogenic Mutations of p110α Isoform of PI 3-Kinase Upregulate Its Protein Kinase Activity
por: Buchanan, Christina M., et al.
Publicado: (2013)

Cyclin-dependent kinase 11(p110) (CDK11(p110)) is crucial for human breast cancer cell proliferation and growth
por: Zhou, Yubing, et al.
Publicado: (2015)

Conduction-band states in GaSb(110) and GaP(110) at the Brillouin-zone center
por: Faul, J, et al.
Publicado: (1993)

Phosphoinositide-3-kinases p110α and p110β mediate S phase entry in astroglial cells in the marginal zone of rat neocortex
por: Müller, Rabea, et al.
Publicado: (2013)

Dynamics of the Phosphoinositide 3-Kinase p110δ Interaction with p85α and Membranes Reveals Aspects of Regulation Distinct from p110α
por: Burke, John E., et al.
Publicado: (2011)

Antigen receptor signalling: a distinctive role for the p110δ isoform of PI3K
por: Okkenhaug, Klaus, et al.
Publicado: (2007)

Targeted inhibition of phosphatidyl inositol-3-kinase p110β, but not p110α, enhances apoptosis and sensitivity to paclitaxel in chemoresistant ovarian cancers
por: Jeong, Ju-yeon, et al.
Publicado: (2013)

Insulin Granule Recruitment and Exocytosis Is Dependent on p110γ in Insulinoma and Human β-Cells
por: Pigeau, Gary M., et al.
Publicado: (2009)

Higher-order oligomerization of Spc110p drives γ-tubulin ring complex assembly
por: Lyon, Andrew S., et al.
Publicado: (2016)

Inhibition of PI3 kinase isoform p110α suppresses neuroblastoma growth and induces the reduction of Anaplastic Lymphoma Kinase
por: Guo, Yue, et al.
Publicado: (2022)

Phosphatidylinositol 3-kinase p110δ expression in Merkel cell carcinoma
por: Chteinberg, Emil, et al.
Publicado: (2018)

The PI3K subunits, P110α and P110β are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer
por: Zhang, Lei, et al.
Publicado: (2020)

Dominant Role of PI3K p110α over p110β in Insulin and β-Adrenergic Receptor Signalling
por: Zhang, Biqin, et al.
Publicado: (2021)

Functional impact and molecular binding modes of drugs that target the PI3K isoform p110δ
por: Hassenrück, Floyd, et al.
Publicado: (2023)

G protein βγ translocation to the Golgi apparatus activates MAPK via p110γ-p101 heterodimers
por: Khater, Mostafa, et al.
Publicado: (2021)

Regulation of p110δ PI 3-Kinase Gene Expression
por: Kok, Klaartje, et al.
Publicado: (2009)

PI3K inhibitors in thrombosis and cardiovascular disease
por: Durrant, Tom N., et al.
Publicado: (2020)

mTORC2 Protein-mediated Protein Kinase B (Akt) Serine 473 Phosphorylation Is Not Required for Akt1 Activity in Human Platelets
por: Moore, Samantha F., et al.
Publicado: (2011)

Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain
por: Harris, Noah J, et al.
Publicado: (2023)

Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain
por: Harris, Noah J, et al.
Publicado: (2023)

Structure of the phosphoinositide 3-kinase (PI3K) p110γ-p101 complex reveals molecular mechanism of GPCR activation
por: Rathinaswamy, Manoj K., et al.
Publicado: (2021)

Aggressive neuroblastomas have high p110alpha but low p110delta and p55alpha/p50alpha protein levels compared to low stage neuroblastomas
por: Fransson, Susanne, et al.
Publicado: (2013)

PTEN regulated PI3K-p110 and AKT isoform plasticity controls metastatic prostate cancer progression
por: Miller, Karina, et al.
Publicado: (2023)

Letter of intent: study of $\overline{p}p$ interactions with the R-110 detector
por: Besch, H J, et al.
Publicado: (1980)

p110δ PI3 kinase pathway: emerging roles in cancer
por: Tzenaki, Niki, et al.
Publicado: (2013)

Requirement for Interaction of PI3-Kinase p110α with RAS in Lung Tumor Maintenance
por: Castellano, Esther, et al.
Publicado: (2013)

The influence of the structure of the Au(110) surface on the ordering of a monolayer of cytochrome P450 reductase at the Au(110)/phosphate buffer interface
por: Smith, C. I., et al.
Publicado: (2014)

The PI3K p110α isoform regulates endothelial adherens junctions via Pyk2 and Rac1
por: Cain, Robert J., et al.
Publicado: (2010)

PI3K p110α and p110β have differential effects on Akt activation and protection against oxidative stress-induced apoptosis in myoblasts
por: Matheny, Ronald W., et al.
Publicado: (2009)

Pascin: 110 drawings
por: Pascin, Jules, 1885-1930
Publicado: (1972)

Distribution of £110,000
Publicado: (1920)

Cannot write session to /tmp/vufind_sessions/sess_qhku87ain7trllgpmq6srnnmgt