FOXM1 modulates 5-FU resistance in colorectal cancer through regulating TYMS expression

Resistance to 5-Fluoruracil (5-FU) has been linked to elevated expression of the main target, thymidylate synthase (TYMS), which catalyses the de novo pathway for production of deoxythymidine monophosphate. The potent oncogenic forkhead box transcription factor, FOXM1 is is regulated by E2F1 which a...

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Detalles Bibliográficos
Autores principales: Varghese, Vidhya, Magnani, Luca, Harada-Shoji, Narumi, Mauri, Francesco, Szydlo, Richard M., Yao, Shang, Lam, Eric W.-F., Kenny, Laura M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365533/
https://www.ncbi.nlm.nih.gov/pubmed/30728402
http://dx.doi.org/10.1038/s41598-018-38017-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365533/
https://www.ncbi.nlm.nih.gov/pubmed/30728402
http://dx.doi.org/10.1038/s41598-018-38017-0

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