Elevated apoptosis impairs epithelial cell turnover and shortens villi in TNF-driven intestinal inflammation

The intestinal epithelial monolayer, at the boundary between microbes and the host immune system, plays an important role in the development of inflammatory bowel disease (IBD), particularly as a target and producer of pro-inflammatory TNF. Chronic overexpression of TNF leads to IBD-like pathology o...

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Detalles Bibliográficos
Autores principales: Parker, Aimée, Vaux, Laura, Patterson, Angela M., Modasia, Amisha, Muraro, Daniele, Fletcher, Alexander G., Byrne, Helen M., Maini, Philip K., Watson, Alastair J. M., Pin, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365534/
https://www.ncbi.nlm.nih.gov/pubmed/30728350
http://dx.doi.org/10.1038/s41419-018-1275-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365534/
https://www.ncbi.nlm.nih.gov/pubmed/30728350
http://dx.doi.org/10.1038/s41419-018-1275-5

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