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Elevated apoptosis impairs epithelial cell turnover and shortens villi in TNF-driven intestinal inflammation
The intestinal epithelial monolayer, at the boundary between microbes and the host immune system, plays an important role in the development of inflammatory bowel disease (IBD), particularly as a target and producer of pro-inflammatory TNF. Chronic overexpression of TNF leads to IBD-like pathology o...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365534/ https://www.ncbi.nlm.nih.gov/pubmed/30728350 http://dx.doi.org/10.1038/s41419-018-1275-5 |