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Aryl Azides as Phosphine-Activated Switches for Small Molecule Function

Engineered small molecule triggers are important tools for the control and investigation of biological processes, in particular protein function. Staudinger reductions of aryl azides to amines through the use of phosphines can trigger an elimination reaction, and thereby activation of a functional m...

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Detalles Bibliográficos
Autores principales: Lukasak, Bradley, Morihiro, Kunihiko, Deiters, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365568/
https://www.ncbi.nlm.nih.gov/pubmed/30728367
http://dx.doi.org/10.1038/s41598-018-37023-6